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Target
Carbonic anhydrase 2
Ligand
BDBM50159808
Substrate
n/a
Meas. Tech.
ChEMBL_302729 (CHEMBL838677)
Ki
9.4±n/a nM
Citation
 Winum, JY; Pastorekova, S; Jakubickova, L; Montero, JL; Scozzafava, A; Pastorek, J; Vullo, D; Innocenti, A; Supuran, CT Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. Bioorg Med Chem Lett 15:579-84 (2005) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50159808
Synonyms:
CHEMBL182429 | Sulfamic acid 3-sulfamoyloxy-phenyl ester
Type:
Small organic molecule
Emp. Form.:
C6H8N2O6S2
Mol. Mass.:
268.268
SMILES:
NS(=O)(=O)Oc1cccc(OS(N)(=O)=O)c1
Structure:
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