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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50159021
Substrate
n/a
Meas. Tech.
ChEMBL_303199 (CHEMBL829825)
Ki
0.3±n/a nM
Citation
 Costantino, L; Gandolfi, F; Sorbi, C; Franchini, S; Prezzavento, O; Vittorio, F; Ronsisvalle, G; Leonardi, A; Poggesi, E; Brasili, L Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands. J Med Chem 48:266-73 (2005) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50159021
Synonyms:
1-Benzyl-4-chroman-3-ylmethyl-piperazine | 1-benzyl-4-((3,4-dihydro-2H-chromen-3-yl)methyl)piperazine | CHEMBL362699
Type:
Small organic molecule
Emp. Form.:
C21H26N2O
Mol. Mass.:
322.4439
SMILES:
C(C1COc2ccccc2C1)N1CCN(Cc2ccccc2)CC1
Structure:
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