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Target
Alpha-amylase
Ligand
BDBM50174835
Substrate
n/a
Meas. Tech.
ChEMBL_326642 (CHEMBL868756)
IC50
87800±n/a nM
Citation
 Seo, WD; Kim, JH; Kang, JE; Ryu, HW; Curtis-Long, MJ; Lee, HS; Yang, MS; Park, KH Sulfonamide chalcone as a new class of alpha-glucosidase inhibitors. Bioorg Med Chem Lett 15:5514-6 (2005) [PubMed]  Article 
Target
Name:
Alpha-amylase
Synonyms:
AMY_BACLI | amyL | amyS
Type:
PROTEIN
Mol. Mass.:
58553.00
Organism:
Bacillus licheniformis
Description:
ChEMBL_326642
Residue:
512
Sequence:
MKQQKRLYARLLTLLFALIFLLPHSAAAAANLNGTLMQYFEWYMPNDGQHWKRLQNDSAYLAEHGITAVWIPPAYKGTSQADVGYGAYDLYDLGEFHQKGTVRTKYGTKGELQSAIKSLHSRDINVYGDVVINHKGGADATEDVTAVEVDPADRNRVISGEHRIKAWTHFHFPGRGSTYSDFKWHWYHFDGTDWDESRKLNRIYKFQGKAWDWEVSNENGNYDYLMYADIDYDHPDVAAEIKRWGTWYANELQLDGFRLDAVKHIKFSFLRDWVNHVREKTGKEMFTVAEYWQNDLGALENYLNKTNFNHSVFDVPLHYQFHAASTQGGGYDMRKLLNSTVVSKHPLKAVTFVDNHDTQPGQSLESTVQTWFKPLAYAFILTRESGYPQVFYGDMYGTKGDSQREIPALKHKIEPILKARKQYAYGAQHDYFDHHDIVGWTREGDSSVANSGLAALITDGPGGAKRMYVGRQNAGETWHDITGNRSEPVVINSEGWGEFHVNGGSVSIYVQR
  
Inhibitor
Name:
BDBM50174835
Synonyms:
4'-(4-toluenesulfonamido)-4-hydroxychalcone | 4'-(p-Toluenesulfonamide)-4-hydroxychalcone | CHEMBL371723 | N-(4-(3-(4-hydroxyphenyl)acryloyl)phenyl)-4-methylbenzenesulfonamide | Sulfonamide chalcone, 4
Type:
Small organic molecule
Emp. Form.:
C22H19NO4S
Mol. Mass.:
393.456
SMILES:
Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)C(=O)\C=C\c1ccc(O)cc1
Structure:
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