Reaction Details Report a problem with these data
Target
Sodium- and chloride-dependent GABA transporter 1
Ligand
BDBM50020883
Substrate
n/a
Meas. Tech.
ChEMBL_329152 (CHEMBL862288)
IC50
81500±n/a nM
Citation
 Zheng, J; Wen, R; Luo, X; Lin, G; Zhang, J; Xu, L; Guo, L; Jiang, H Design, synthesis, and biological evaluation of the N-diarylalkenyl-piperidinecarboxylic acid derivatives as GABA uptake inhibitors (I). Bioorg Med Chem Lett 16:225-7 (2005) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent GABA transporter 1
Synonyms:
GABA transporter 1 | GABATR | GABT1 | GAT-1 | GAT1 | SC6A1_HUMAN | SLC6A1 | Sodium- and chloride-dependent GABA transporter 1 | Solute carrier family 6 member 1
Type:
PROTEIN
Mol. Mass.:
67079.40
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1454196
Residue:
599
Sequence:
MATNGSKVADGQISTEVSEAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSMVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRIQVMVQPSEDIVRPENGPEQPQAGSSTSKEAYI
  
Inhibitor
Name:
BDBM50020883
Synonyms:
(R)-Piperidine-3-carboxylic acid | (R)-nipecotic acid | CHEMBL77575 | Nipecotic acid
Type:
Small organic molecule
Emp. Form.:
C6H11NO2
Mol. Mass.:
129.157
SMILES:
OC(=O)[C@@H]1CCCNC1 |r|
Structure:
Search PDB for entries with ligand similarity: