Target
Aurora kinase A
Ligand
BDBM50181553
Substrate
n/a
Meas. Tech.
ChEMBL_420088 (CHEMBL873731)
IC50
>1000±n/a nM
Citation
 Jung, FHPasquet, GLambert-van der Brempt, CLohmann, JJWarin, NRenaud, FGermain, HDe Savi, CRoberts, NJohnson, TDousson, CHill, GBMortlock, AAHeron, NWilkinson, RWWedge, SRHeaton, SPOdedra, RKeen, NJGreen, SBrown, EThompson, KBrightwell, S Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors. J Med Chem 49:955-70 (2006) [PubMed]  Article 
Target
Name:
Aurora kinase A
Synonyms:
AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45830.98
Organism:
Homo sapiens (Human)
Description:
O14965
Residue:
403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
  
Inhibitor
Name:
BDBM50181553
Synonyms:
CHEMBL202370 | N-(4-fluorophenyl)-2-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]amino}-1H-imidazole-5-carboxamide
Type:
Small organic molecule
Emp. Form.:
C26H28FN7O4
Mol. Mass.:
521.5434
SMILES:
COc1cc2c(Nc3ncc([nH]3)C(=O)Nc3ccc(F)cc3)ncnc2cc1OCCCN1CCOCC1
Structure:
Search PDB for entries with ligand similarity: