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Target
Cysteine protease falcipain-3 [5-492]
Ligand
BDBM50183405
Substrate
n/a
Meas. Tech.
ChEMBL_336665 (CHEMBL862348)
IC50
>50000±n/a nM
Citation
 Desai, PV; Patny, A; Gut, J; Rosenthal, PJ; Tekwani, B; Srivastava, A; Avery, M Identification of novel parasitic cysteine protease inhibitors by use of virtual screening. 2. The available chemical directory. J Med Chem 49:1576-84 (2006) [PubMed]  Article 
Target
Name:
Cysteine protease falcipain-3 [5-492]
Synonyms:
Cysteine protease falcipain-3 | Q9NAW4_PLAFA
Type:
PROTEIN
Mol. Mass.:
56106.86
Organism:
Plasmodium falciparum
Description:
ChEMBL_430127
Residue:
488
Sequence:
MEYSPNEVIKQEREVFVGKEKSGSKFKRKRSIFIVLTVSICFMFALMLFYFTRNENNKTLFTNSLSNNINDDYIINSLLKSESGKKFIVSKLEELISSYDKEKKMRTTGAEENNMNMNGIDDKDNKSVSFVNKKNGNLKVNNNNQVSYSNLFDTKFLMDNLETVNLFYIFLKENNKKYETSEEMQKRFIIFSENYRKIELHNKKTNSLYKRGMNKFGDLSPEEFRSKYLNLKTHGPFKTLSPPVSYEANYEDVIKKYKPADAKLDRIAYDWRLHGGVTPVKDQALCGSCWAFSSVGSVESQYAIRKKALFLFSEQELVDCSVKNNGCYGGYITNAFDDMIDLGGLCSQDDYPYVSNLPETCNLKRCNERYTIKSYVSIPDDKFKEALRYLGPISISIAASDDFAFYRGGFYDGECGAAPNHAVILVGYGMKDIYNEDTGRMEKFYYYIIKNSWGSDWGEGGYINLETDENGYKKTCSIGTEAYVPLLE
  
Inhibitor
Name:
BDBM50183405
Synonyms:
4,6-dimethyl-N,N-bis(2-(phenylsulfonyl)ethyl)-1,3,5-triazin-2-amine | CHEMBL380140
Type:
Small organic molecule
Emp. Form.:
C21H24N4O4S2
Mol. Mass.:
460.57
SMILES:
Cc1nc(C)nc(n1)N(CCS(=O)(=O)c1ccccc1)CCS(=O)(=O)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: