Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM50189847
Substrate
n/a
Meas. Tech.
ChEMBL_367035 (CHEMBL864944)
Ki
8700±n/a nM
Citation
 Enguehard-Gueiffier, C; Hübner, H; El Hakmaoui, A; Allouchi, H; Gmeiner, P; Argiolas, A; Melis, MR; Gueiffier, A 2-[(4-phenylpiperazin-1-yl)methyl]imidazo(di)azines as selective D4-ligands. Induction of penile erection by 2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine (PIP3EA), a potent and selective D4 partial agonist. J Med Chem 49:3938-47 (2006) [PubMed]  Article 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DRD1 | DRD1_PIG | Dopamine D1 receptor
Type:
PROTEIN
Mol. Mass.:
49269.92
Organism:
Sus scrofa
Description:
ChEMBL_1460140
Residue:
446
Sequence:
MRTLNTSTMDGTGLVVERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNVTSLGKTTHNCDSSLSRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPAECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCGSGETKPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPTSTNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIASPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM50189847
Synonyms:
2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]-6-methyl-8-(pyrazol-1-yl)imidazo[1,2-a]pyridine | CHEMBL210551
Type:
Small organic molecule
Emp. Form.:
C23H26N6O
Mol. Mass.:
402.4921
SMILES:
COc1ccccc1N1CCN(Cc2cn3cc(C)cc(-n4cccn4)c3n2)CC1
Structure:
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