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Target
Heme oxygenase 2
Ligand
BDBM50183063
Substrate
n/a
Meas. Tech.
ChEMBL_368942 (CHEMBL869061)
IC50
532000±n/a nM
Citation
 Vlahakis, JZ; Kinobe, RT; Bowers, RJ; Brien, JF; Nakatsu, K; Szarek, WA Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors. J Med Chem 49:4437-41 (2006) [PubMed]  Article 
Target
Name:
Heme oxygenase 2
Synonyms:
HMOX2_RAT | Heme Oxygenase 2 (HO-2) | Heme oxygenase 2 | Hmox2
Type:
Enzyme
Mol. Mass.:
35754.99
Organism:
Rattus norvegicus (rat)
Description:
HO-2 obtained from rat brain was used in enzyme assays.
Residue:
315
Sequence:
MSSEVETSEGVDESENNSTAPEKENHTKMADLSELLKEGTKEAHDRAENTQFVKDFLKGNIKKELFKLATTALYFTYSALEEEMDRNKDHPAFAPLYFPTELHRKEALIKDMEYFFGENWEEQVKCSEAAQKYVDRIHYVGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPSTGEGTQFYLFEHVDNAQQFKQFYRARMNALDLSMKTKERIVEEANKAFEYNMQIFSELDQAGSMLTKETLEDGLPVHDGKGDVRKCPFYAAQPDKGTLGGSNCPFRTAMAVLRKPSLQLILAASVALVAGLLAWYYM
  
Inhibitor
Name:
BDBM50183063
Synonyms:
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)-methyl]-4-methyl-1,3-dioxolane hydrochloride | 1-(((2R,4R)-2-(4-chlorophenethyl)-4-methyl-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride | CHEMBL536056
Type:
Small organic molecule
Emp. Form.:
C16H19ClN2O2
Mol. Mass.:
306.787
SMILES:
C[C@@H]1CO[C@@](CCc2ccc(Cl)cc2)(Cn2ccnc2)O1
Structure:
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