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Target
Heme oxygenase 2
Ligand
BDBM50183062
Substrate
n/a
Meas. Tech.
ChEMBL_368936 (CHEMBL869047)
IC50
>100000±n/a nM
Citation
 Vlahakis, JZ; Kinobe, RT; Bowers, RJ; Brien, JF; Nakatsu, K; Szarek, WA Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors. J Med Chem 49:4437-41 (2006) [PubMed]  Article 
Target
Name:
Heme oxygenase 2
Synonyms:
HMOX2_RAT | Heme Oxygenase 2 (HO-2) | Heme oxygenase 2 | Hmox2
Type:
Enzyme
Mol. Mass.:
35754.99
Organism:
Rattus norvegicus (rat)
Description:
HO-2 obtained from rat brain was used in enzyme assays.
Residue:
315
Sequence:
MSSEVETSEGVDESENNSTAPEKENHTKMADLSELLKEGTKEAHDRAENTQFVKDFLKGNIKKELFKLATTALYFTYSALEEEMDRNKDHPAFAPLYFPTELHRKEALIKDMEYFFGENWEEQVKCSEAAQKYVDRIHYVGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPSTGEGTQFYLFEHVDNAQQFKQFYRARMNALDLSMKTKERIVEEANKAFEYNMQIFSELDQAGSMLTKETLEDGLPVHDGKGDVRKCPFYAAQPDKGTLGGSNCPFRTAMAVLRKPSLQLILAASVALVAGLLAWYYM
  
Inhibitor
Name:
BDBM50183062
Synonyms:
1-((2-(2-(4-chlorophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride | 1-((2-(4-chlorophenethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride | 2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride | CHEMBL495072 | CHEMBL541899
Type:
Small organic molecule
Emp. Form.:
C15H17ClN2O2
Mol. Mass.:
292.761
SMILES:
Clc1ccc(CCC2(Cn3ccnc3)OCCO2)cc1
Structure:
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