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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Ligand
BDBM50187060
Substrate
n/a
Meas. Tech.
ChEMBL_375630 (CHEMBL871428)
IC50
50000±n/a nM
Citation
 Kim, ND; Yoon, J; Kim, JH; Lee, JT; Chon, YS; Hwang, MK; Ha, I; Song, WJ Putative therapeutic agents for the learning and memory deficits of people with Down syndrome. Bioorg Med Chem Lett 16:3772-6 (2006) [PubMed]  Article 
Target
Name:
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Synonyms:
DYR1A_MOUSE | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Dyrk | Dyrk1a
Type:
PROTEIN
Mol. Mass.:
85526.58
Organism:
Mus musculus
Description:
ChEMBL_631605
Residue:
763
Sequence:
MHTGGETSACKPSSVRLAPSFSFHAAGLQMAAQMPHSHQYSDRRQPSISDQQVSALPYSDQIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWSLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFAAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPAHYMTEGHLAMRQGADREESPMTGVCVQQSPVASS
  
Inhibitor
Name:
BDBM50187060
Synonyms:
(Z)-3-(2-(4-fluorophenylamino)-4-oxothiazol-5(4H)-ylidene)-1-methylindolin-2-one | CHEMBL212045
Type:
Small organic molecule
Emp. Form.:
C18H12FN3O2S
Mol. Mass.:
353.37
SMILES:
CN1C(=O)C(=C2SC(Nc3ccc(F)cc3)=NC2=O)c2ccccc12 |w:4.3,c:16|
Structure:
Search PDB for entries with ligand similarity: