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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Ligand
BDBM50187062
Substrate
n/a
Meas. Tech.
ChEMBL_375630 (CHEMBL871428)
IC50
20000±n/a nM
Citation
 Kim, ND; Yoon, J; Kim, JH; Lee, JT; Chon, YS; Hwang, MK; Ha, I; Song, WJ Putative therapeutic agents for the learning and memory deficits of people with Down syndrome. Bioorg Med Chem Lett 16:3772-6 (2006) [PubMed]  Article 
Target
Name:
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Synonyms:
DYR1A_MOUSE | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Dyrk | Dyrk1a
Type:
PROTEIN
Mol. Mass.:
85526.58
Organism:
Mus musculus
Description:
ChEMBL_631605
Residue:
763
Sequence:
MHTGGETSACKPSSVRLAPSFSFHAAGLQMAAQMPHSHQYSDRRQPSISDQQVSALPYSDQIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWSLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFAAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPAHYMTEGHLAMRQGADREESPMTGVCVQQSPVASS
  
Inhibitor
Name:
BDBM50187062
Synonyms:
5-(5-(2-(allyloxy)-5-bromobenzylidene)-4-oxo-4,5-dihydrothiazol-2-ylamino)-2-chlorobenzoic acid | CHEMBL211705
Type:
Small organic molecule
Emp. Form.:
C20H14BrClN2O4S
Mol. Mass.:
493.758
SMILES:
OC(=O)c1cc(NC2=NC(=O)C(S2)=Cc2cc(Br)ccc2OCC=C)ccc1Cl |w:13.14,t:7|
Structure:
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