Reaction Details Report a problem with these data
Target
RNA-directed RNA polymerase
Ligand
BDBM50162092
Substrate
n/a
Meas. Tech.
ChEMBL_391864 (CHEMBL862448)
IC50
30±n/a nM
Citation
 Beaulieu, PL; Gillard, J; Bykowski, D; Brochu, C; Dansereau, N; Duceppe, JS; Haché, B; Jakalian, A; Lagacé, L; LaPlante, S; McKercher, G; Moreau, E; Perreault, S; Stammers, T; Thauvette, L; Warrington, J; Kukolj, G Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: from benzimidazole to indole scaffolds. Bioorg Med Chem Lett 16:4987-93 (2006) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50162092
Synonyms:
3-Cyclohexyl-1-methyl-2-phenyl-1H-indole-6-carboxylic acid | CHEMBL425693
Type:
Small organic molecule
Emp. Form.:
C22H23NO2
Mol. Mass.:
333.4235
SMILES:
Cn1c(c(C2CCCCC2)c2ccc(cc12)C(O)=O)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: