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Target
RNA-directed RNA polymerase
Ligand
BDBM50137479
Substrate
n/a
Meas. Tech.
ChEMBL_391864 (CHEMBL862448)
IC50
3100±n/a nM
Citation
 Beaulieu, PL; Gillard, J; Bykowski, D; Brochu, C; Dansereau, N; Duceppe, JS; Haché, B; Jakalian, A; Lagacé, L; LaPlante, S; McKercher, G; Moreau, E; Perreault, S; Stammers, T; Thauvette, L; Warrington, J; Kukolj, G Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: from benzimidazole to indole scaffolds. Bioorg Med Chem Lett 16:4987-93 (2006) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50137479
Synonyms:
1-Cyclohexyl-2-phenyl-1H-benzoimidazole-5-carboxylic acid | 1-cyclohexyl-2-phenyl-1H-benzo[d]imidazole-5-carboxylic acid | CHEMBL361434
Type:
Small organic molecule
Emp. Form.:
C20H20N2O2
Mol. Mass.:
320.385
SMILES:
OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: