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Target
P2Y purinoceptor 6
Ligand
BDBM50194150
Substrate
n/a
Meas. Tech.
ChEMBL_402044 (CHEMBL866173)
EC50
3500±n/a nM
Citation
 Besada, P; Shin, DH; Costanzi, S; Ko, H; Mathé, C; Gagneron, J; Gosselin, G; Maddileti, S; Harden, TK; Jacobson, KA Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor. J Med Chem 49:5532-43 (2006) [PubMed]  Article 
Target
Name:
P2Y purinoceptor 6
Synonyms:
P2RY6 | P2RY6_HUMAN | P2Y purinoceptor 6 | P2Y6 | Pyrimidinergic receptor P2Y6
Type:
PROTEIN
Mol. Mass.:
36452.29
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1511151
Residue:
328
Sequence:
MEWDNGTGQALGLPPTTCVYRENFKQLLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRRPHELLQKLTAKWQRQGR
  
Inhibitor
Name:
BDBM50194150
Synonyms:
(1S,3R,4R,5S)-1-(4-hydroxy-1-(diphosphoryloxymethyl)-2-oxabicyclo[3.1.0]hexan-3-yl)pyrimidine-2,4(1H,3H)-dione ammonium salt
Type:
Small organic molecule
Emp. Form.:
C10H14N2O11P2
Mol. Mass.:
400.1725
SMILES:
O[C@@H]1[C@@H]2C[C@]2(COP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(=O)[nH]c1=O
Structure:
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