Target
Histone deacetylase 1
Ligand
BDBM50195110
Substrate
n/a
Meas. Tech.
ChEMBL_422136 (CHEMBL907072)
IC50
930±n/a nM
Citation
 Jones, PAltamura, SChakravarty, PKCecchetti, ODe Francesco, RGallinari, PIngenito, RMeinke, PTPetrocchi, ARowley, MScarpelli, RSerafini, SSteinkühler, C A series of novel, potent, and selective histone deacetylase inhibitors. Bioorg Med Chem Lett 16:5948-52 (2006) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50195110
Synonyms:
(S)-2-acetamido-8-oxo-N-(2-(2-phenyl-1H-indol-3-yl)ethyl)nonanamide | CHEMBL216336
Type:
Small organic molecule
Emp. Form.:
C27H33N3O3
Mol. Mass.:
447.5692
SMILES:
CC(=O)CCCCC[C@H](NC(C)=O)C(=O)NCCc1c([nH]c2ccccc12)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: