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Target
Histone deacetylase 7
Ligand
BDBM50195108
Substrate
n/a
Meas. Tech.
ChEMBL_422135 (CHEMBL907071)
IC50
4200±n/a nM
Citation
 Jones, P; Altamura, S; Chakravarty, PK; Cecchetti, O; De Francesco, R; Gallinari, P; Ingenito, R; Meinke, PT; Petrocchi, A; Rowley, M; Scarpelli, R; Serafini, S; Steinkühler, C A series of novel, potent, and selective histone deacetylase inhibitors. Bioorg Med Chem Lett 16:5948-52 (2006) [PubMed]  Article 
Target
Name:
Histone deacetylase 7
Synonyms:
HD7 | HDAC7 | HDAC7A | HDAC7_HUMAN | Histone acetylase 7 (HDAC7) | Histone deacetylase 7A | Human HDAC7
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
102942.62
Organism:
Homo sapiens (Human)
Description:
Q8WUI4
Residue:
952
Sequence:
MDLRVGQRPPVEPPPEPTLLALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLSVGILAEDRPSEQLVEEEEPMNL
  
Inhibitor
Name:
BDBM50195108
Synonyms:
(S)-N8-hydroxy-2-(2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamido)-N1-(2-(2-phenyl-1H-indol-3-yl)ethyl)octanediamide | CHEMBL216641
Type:
Small organic molecule
Emp. Form.:
C36H41N5O5
Mol. Mass.:
623.7412
SMILES:
COc1ccc2[nH]c(C)c(CC(=O)N[C@@H](CCCCCC(=O)NO)C(=O)NCCc3c([nH]c4ccccc34)-c3ccccc3)c2c1
Structure:
Search PDB for entries with ligand similarity: