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Target
Peptide deformylase 1A, chloroplastic/mitochondrial
Ligand
BDBM50089194
Substrate
n/a
Meas. Tech.
ChEMBL_423228 (CHEMBL912247)
IC50
27±n/a nM
Citation
 Boularot, A; Giglione, C; Petit, S; Duroc, Y; Alves de Sousa, R; Larue, V; Cresteil, T; Dardel, F; Artaud, I; Meinnel, T Discovery and refinement of a new structural class of potent peptide deformylase inhibitors. J Med Chem 50:10-20 (2007) [PubMed]  Article 
Target
Name:
Peptide deformylase 1A, chloroplastic/mitochondrial
Synonyms:
AtDEF1 | AtDEF1A | DEF1 | DEF1A_ARATH | PDF 1A | PDF1A | Peptide deformylase 1A, chloroplastic | Polypeptide deformylase
Type:
PROTEIN
Mol. Mass.:
30001.50
Organism:
Arabidopsis thaliana
Description:
ChEMBL_423228
Residue:
269
Sequence:
MGLHRDEATAMETLFRVSLRLLPVSAAVTCRSIRFPVSRPGSSHLLNRKLYNLPTSSSSSLSTKAGWLLGLGEKKKKVDLPEIVASGDPVLHEKAREVDPGEIGSERIQKIIDDMIKVMRLAPGVGLAAPQIGVPLRIIVLEDTKEYISYAPKEEILAQERRHFDLMVMVNPVLKERSNKKALFFEGCLSVDGFRAAVERYLEVVVTGYDRQGKRIEVNASGWQARILQHECDHLDGNLYVDKMVPRTFRTVDNLDLPLAEGCPKLGPQ
  
Inhibitor
Name:
BDBM50089194
Synonyms:
(R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-pyrrolidine-1-carbonyl)-2-methyl-propyl]-2-pentyl-succinamide | (R)-N4-hydroxy-N1-((S)-1-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)-2-pentylsuccinamide | ACTINONIN | CHEMBL308333 | N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-pyrrolidine-1-carbonyl)-2-methyl-propyl]-2-(R)-pentyl-succinamide | N*4*-Hydroxy-N*1*-[1-(2-hydroxymethyl-pyrrolidine-1-carbonyl)-2-methyl-propyl]-2-pentyl-succinamide
Type:
Small organic molecule
Emp. Form.:
C19H35N3O5
Mol. Mass.:
385.4983
SMILES:
CCCCC[C@H](CC(=O)NO)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1CO
Structure:
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