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Target
UDP-glucose 4-epimerase
Ligand
BDBM50194601
Substrate
n/a
Meas. Tech.
ChEMBL_424499 (CHEMBL911909)
IC50
500±n/a nM
Citation
 Urbaniak, MD; Tabudravu, JN; Msaki, A; Matera, KM; Brenk, R; Jaspars, M; Ferguson, MA Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness. Bioorg Med Chem Lett 16:5744-7 (2006) [PubMed]  Article 
Target
Name:
UDP-glucose 4-epimerase
Synonyms:
GALE | GALE_HUMAN
Type:
PROTEIN
Mol. Mass.:
38282.25
Organism:
Homo sapiens (Human)
Description:
ChEMBL_424499
Residue:
348
Sequence:
MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA
  
Inhibitor
Name:
BDBM50194601
Synonyms:
1,2,4-Trichloro-5-(3-iodo-prop-2-ynyloxy)-benzene | 1,2,4-trichloro-5-(3-iodoprop-2-ynyloxy)benzene | CHEMBL1289 | HALOPROGIN | Halotex | M-1028
Type:
Small organic molecule
Emp. Form.:
C9H4Cl3IO
Mol. Mass.:
361.391
SMILES:
Clc1cc(Cl)c(OCC#CI)cc1Cl
Structure:
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