Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50205717
Substrate
n/a
Meas. Tech.
ChEMBL_428388 (CHEMBL917988)
Ki
1.7±n/a nM
Citation
 Volpini, R; Dal Ben, D; Lambertucci, C; Taffi, S; Vittori, S; Klotz, KN; Cristalli, G N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem 50:1222-30 (2007) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50205717
Synonyms:
(2S,3S,4R)-3,4-dihydroxy-5-((S)-2-iodo-6-methoxyamino-9H-purin-3-yl)-tetrahydro-furan-2-carboxylic acid methylamide | CHEMBL385771
Type:
Small organic molecule
Emp. Form.:
C12H15IN6O5
Mol. Mass.:
450.1892
SMILES:
CNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NOC)nc(I)nc12
Structure:
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