Reaction Details Report a problem with these data
Target
RmtA
Ligand
BDBM50206427
Substrate
n/a
Meas. Tech.
ChEMBL_434652 (CHEMBL914209)
IC50
33800±n/a nM
Citation
 Spannhoff, A; Heinke, R; Bauer, I; Trojer, P; Metzger, E; Gust, R; Schüle, R; Brosch, G; Sippl, W; Jung, M Target-based approach to inhibitors of histone arginine methyltransferases. J Med Chem 50:2319-25 (2007) [PubMed]  Article 
Target
Name:
RmtA
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
39351.26
Organism:
Emericella nidulans
Description:
ChEMBL_475539
Residue:
345
Sequence:
MSEIENSTITSSADRMVGMDHAEVRYFTSYDHHGIHEEMLKDDVRTRSYRDSIYQNRHIFKDKVVLDVGCGTGILSMFAAKAGAKHVIGVDMSSIIEKAREIVAVNGLADKITLLQGKMEEVQLPFPSVDIIISEWMGYFLLYESMLDTVLYAQDRYLVPGGKIFPDKATMYLAGIEDGEYKDDKIGFWDNVYGFDYSPMKEIALTEPLVDTVELKALVTDPCPIITFDLYTVTKEDLAFEVPYSLPVKRSDFVHAVIAWFDIEFGACHKPINFSTGPHAKYTHWKQTVFYLRDVLTVEEEESISGVLSNRPNDKNKRDLDINLTYKLETQDQTRFAEGGCFYRM
  
Inhibitor
Name:
BDBM50206427
Synonyms:
7,7'-carbonylbis(azanediyl)bis(4-hydroxynaphthalene-2-sulfonic acid) | AMI-1 | CHEMBL221047
Type:
Small organic molecule
Emp. Form.:
C21H16N2O9S2
Mol. Mass.:
504.49
SMILES:
Oc1cc(cc2cc(NC(=O)Nc3ccc4c(O)cc(cc4c3)S(O)(=O)=O)ccc12)S(O)(=O)=O
Structure:
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