Reaction Details Report a problem with these data
Target
Enoyl-acyl-carrier protein reductase
Ligand
BDBM50211929
Substrate
n/a
Meas. Tech.
ChEMBL_436468 (CHEMBL904777)
IC50
>100000±n/a nM
Citation
 Kumar, G; Parasuraman, P; Sharma, SK; Banerjee, T; Karmodiya, K; Surolia, N; Surolia, A Discovery of a rhodanine class of compounds as inhibitors of Plasmodium falciparum enoyl-acyl carrier protein reductase. J Med Chem 50:2665-75 (2007) [PubMed]  Article 
Target
Name:
Enoyl-acyl-carrier protein reductase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
49770.86
Organism:
Plasmodium falciparum
Description:
ChEMBL_795989
Residue:
432
Sequence:
MNKISQRLLFLFLHFYTTVCFIQNNTQKTFHNVLQNEQIRGKEKAFYRKEKRENIFIGNKMKHVHNMNNTHNNNHYMEKEEQDASNINKIKEENKNEDICFIAGIGDTNGYGWGIAKELSKRNVKIIFGIWPPVYNIFMKNYKNGKFDNDMIIDKDKKMNILDMLPFDASFDTANDIDEETKNNKRYNMLQNYPIEDVANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSKSSYSLISLCKYFVNIMKPQSSIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLAYHLGRNYNIRINTISAGPLKSRAATAINKLNNTYENNTNQNKNRNSHDVHNIMNNSGEKEEKKNSASQNYTFIDYAIEYSEKYAPLRQKLLSTDIGSVASFLLSRESRAITGQTIYVDNGLNIMFLPDDIYRNENE
  
Inhibitor
Name:
BDBM50211929
Synonyms:
CHEMBL390063 | methyl 6-(5-(4-ethylbenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)hexanoate
Type:
Small organic molecule
Emp. Form.:
C19H23NO3S2
Mol. Mass.:
377.521
SMILES:
CCc1ccc(\C=C2/SC(=S)N(CCCCCC(=O)OC)C2=O)cc1
Structure:
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