Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM50198811
Substrate
n/a
Meas. Tech.
ChEMBL_437736 (CHEMBL905921)
IC50
11±n/a nM
Citation
 Noronha, GBarrett, KBoccia, ABrodhag, TCao, JChow, CPDneprovskaia, EDoukas, JFine, RGong, XGritzen, CGu, HHanna, EHood, JDHu, SKang, XKey, JKlebansky, BKousba, ALi, GLohse, DMak, CCMcPherson, APalanki, MSPathak, VPRenick, JShi, FSoll, RSplittgerber, UStoughton, STang, SYee, SZeng, BZhao, NZhu, H Discovery of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine--a potent, orally active Src kinase inhibitor with anti-tumor activity in preclinical assays. Bioorg Med Chem Lett 17:602-8 (2007) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src
Type:
Protein
Mol. Mass.:
59838.60
Organism:
Homo sapiens (Human)
Description:
P12931
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM50198811
Synonyms:
4-(7-(2,6-dimethylphenyl)-6-methylbenzo[e][1,2,4]triazin-3-ylamino)-N-(2-(pyrrolidin-1-yl)ethyl)benzenesulfonamide | CHEMBL230816 | US8481536, 429 | US8481536, 590
Type:
Small organic molecule
Emp. Form.:
C28H32N6O2S
Mol. Mass.:
516.658
SMILES:
Cc1cccc(C)c1-c1cc2nnc(Nc3ccc(cc3)S(=O)(=O)NCCN3CCCC3)nc2cc1C |(-5.05,5.05,;-6.38,4.28,;-7.71,5.05,;-9.05,4.28,;-9.04,2.74,;-7.71,1.97,;-7.71,.43,;-6.38,2.75,;-5.05,1.97,;-3.72,2.74,;-2.39,1.98,;-1.05,2.77,;.3,1.99,;.31,.43,;1.65,-.33,;2.98,.44,;4.31,-.33,;5.64,.44,;5.63,1.99,;4.29,2.75,;2.96,1.97,;6.96,2.76,;6.19,4.09,;7.73,1.43,;8.3,3.53,;9.63,2.75,;10.97,3.52,;12.3,2.75,;12.46,1.23,;13.97,.91,;14.74,2.24,;13.71,3.39,;-1.03,-.34,;-2.38,.43,;-3.72,-.34,;-5.05,.43,;-6.38,-.34,)|
Structure:
Search PDB for entries with ligand similarity: