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Target
Adenosine receptor A3
Ligand
BDBM50224354
Substrate
n/a
Meas. Tech.
ChEMBL_450737 (CHEMBL901020)
Ki
9.2±n/a nM
Citation
 Da Settimo, F; Primofiore, G; Taliani, S; Marini, AM; La Motta, C; Simorini, F; Salerno, S; Sergianni, V; Tuccinardi, T; Martinelli, A; Cosimelli, B; Greco, G; Novellino, E; Ciampi, O; Trincavelli, ML; Martini, C 5-amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: a versatile scaffold to obtain potent and selective A3 adenosine receptor antagonists. J Med Chem 50:5676-84 (2007) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50224354
Synonyms:
CHEMBL398787 | N-benzoyl-N-(1-oxo-2-phenyl-1H-3,3a,5,9b-tetraaza-cyclopenta[a]naphthalen-4-yl)-benzamide
Type:
Small organic molecule
Emp. Form.:
C29H19N5O3
Mol. Mass.:
485.4929
SMILES:
O=C(N(C(=O)c1ccccc1)c1nc2ccccc2n2n1nc(-c1ccccc1)c2=O)c1ccccc1
Structure:
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