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Target
Muscarinic acetylcholine receptor M3
Ligand
BDBM50218053
Substrate
n/a
Meas. Tech.
ChEMBL_457002 (CHEMBL923345)
Ki
1.8±n/a nM
Citation
 Kumar, N; Kaur, K; Aeron, S; Dharmarajan, S; Silamkoti, AD; Mehta, A; Gupta, S; Chugh, A; Gupta, JB; Salman, M; Palle, VP; Cliffe, IA Synthesis and optimization of novel and selective muscarinic M(3) receptor antagonists. Bioorg Med Chem Lett 17:5256-60 (2007) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M3
Synonyms:
ACM3_RAT | Cholinergic, muscarinic M3 | Chrm-3 | Chrm3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
66086.66
Organism:
RAT
Description:
Cholinergic, muscarinic M3 CHRM3 RAT::P08483
Residue:
589
Sequence:
MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVTQLGSYNISQETGNFSSNDTSSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGVKRSSRRKYGRCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSSILNSTKLPSSDNLQVSNEDLGTVDVERNAHKLQAQKSMGDGDNCQKDFTKLPIQLESAVDTGKTSDTNSSADKTTATLPLSFKEATLAKRFALKTRSQITKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKTLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
  
Inhibitor
Name:
BDBM50218053
Synonyms:
(R)-2-cycloheptyl-2-hydroxy-2-phenyl-N-((1S,5R,6s)-3-(1-phenylethyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)acetamide | CHEMBL248811
Type:
Small organic molecule
Emp. Form.:
C28H36N2O2
Mol. Mass.:
432.5976
SMILES:
CC(N1C[C@H]2[C@@H](C1)[C@@H]2NC(=O)C(O)(C1CCCCCC1)c1ccccc1)c1ccccc1 |w:11.13,1.0|
Structure:
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