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Target
Coagulation factor X
Ligand
BDBM50228915
Substrate
n/a
Meas. Tech.
ChEMBL_461701 (CHEMBL927722)
Ki
0.97±n/a nM
Citation
 Varnes, JG; Wacker, DA; Pinto, DJ; Orwat, MJ; Theroff, JP; Wells, B; Galemo, RA; Luettgen, JM; Knabb, RM; Bai, S; He, K; Lam, PY; Wexler, RR Structure-activity relationship and pharmacokinetic profile of 5-ketopyrazole factor Xa inhibitors. Bioorg Med Chem Lett 18:749-54 (2008) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50228915
Synonyms:
1-[2-(3-amino-benzo[d]isoxazol-5-yl)-5-trifluoromethyl-2H-pyrazol-3-yl]-2-[4-(2-dimethylaminomethyl-imidazol-1-yl)-phenyl]-ethanone | CHEMBL442292
Type:
Small organic molecule
Emp. Form.:
C25H22F3N7O2
Mol. Mass.:
509.4831
SMILES:
CN(C)Cc1nccn1-c1ccc(CC(=O)c2cc(nn2-c2ccc3onc(N)c3c2)C(F)(F)F)cc1
Structure:
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