Reaction Details Report a problem with these data
Target
Carboxylic ester hydrolase
Ligand
BDBM50371970
Substrate
n/a
Meas. Tech.
ChEMBL_464387 (CHEMBL930036)
IC50
22±n/a nM
Citation
Wheelock, CE; Nishi, K; Ying, A; Jones, PD; Colvin, ME; Olmstead, MM; Hammock, BD Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). Bioorg Med Chem 16:2114-30 (2008) [PubMed] Article
More Info.:
Target
Name:
Carboxylic ester hydrolase
Synonyms:
Juvenile hormone esterase | Juvenile hormone esterase (JHE)
Type:
Protein
Mol. Mass.:
64567.21
Organism:
Manduca sexta (Moths)
Description:
n/a
Residue:
573
Sequence:
MDARRQVCYYVLALLCVSELSARIPSTEEVVVRTESGWIRGLKRRAEGNKSYASFRGVPYAKQPLGELRFKELQPLEPWQDELDATQEGPVCQQTDVLYGRIMRPRGMSEACIHANIHVPYYALPRDAADKNRFAGLPVLVFIHGGGFAFGSGDSDLHGPEYLVSKDVIVITFNYRLNVYGFLSLNSTSVPGNAGLRDMVTLLKWVQRNAHFFGGRPDDVTLMGQSAGAAATHILSLSKAADGLFRRAILMSGTSSSAFFTTNPVFAQYINKLFVTNIGITATDPEEIHQKLIEMPAEKLNEANRFLLEQFGLTTFFPVVESPINGVTTILDGDPEQLIAKGRGKHIPLIIGFTDAECEIFRRQFEQIDIVSKIKENPGILVPLSVLFSSAPDTVAEITKAMHEKYFKKSVDMEGYIELCTDSYFMYPAISLAIKRARSNGAPVYLYQFSFDGDYSVFREVNHLNFEGAGHIEDLTYVFRTNSMLGGHASFPPHDKDDHMKYWMTSFITNFMKYSNPVTDAKLWPEVRADNLRYQDIDTPDVYQNVKPHSEQRDMLDFFDSIYNWNGTSYCIK