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Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM50372062
Substrate
n/a
Meas. Tech.
ChEMBL_464678 (CHEMBL934070)
Ki
0.36±n/a nM
Citation
 Burch, JD; Belley, M; Fortin, R; Deschênes, D; Girard, M; Colucci, J; Farand, J; Therien, AG; Mathieu, MC; Denis, D; Vigneault, E; Lévesque, JF; Gagné, S; Wrona, M; Xu, D; Clark, P; Rowland, S; Han, Y Structure-activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP(4) receptor. Bioorg Med Chem Lett 18:2048-54 (2008) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Homo sapiens (Human)
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM50372062
Synonyms:
CHEMBL272498
Type:
Small organic molecule
Emp. Form.:
C34H37N3O7S
Mol. Mass.:
631.738
SMILES:
COc1ccccc1CC(=O)NS(=O)(=O)Cc1ccc(N2Cc3c(C2=O)c(OC(C)C)c2cccnc2c3OC(C)C)c(C)c1
Structure:
Search PDB for entries with ligand similarity: