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Target
Cholesteryl ester transfer protein
Ligand
BDBM50094519
Substrate
n/a
Meas. Tech.
ChEMBL_477677 (CHEMBL924743)
IC50
3±n/a nM
Citation
 Harikrishnan, LS; Kamau, MG; Herpin, TF; Morton, GC; Liu, Y; Cooper, CB; Salvati, ME; Qiao, JX; Wang, TC; Adam, LP; Taylor, DS; Chen, AY; Yin, X; Seethala, R; Peterson, TL; Nirschl, DS; Miller, AV; Weigelt, CA; Appiah, KK; O'Connell, JC; Michael Lawrence, R 2-Arylbenzoxazoles as novel cholesteryl ester transfer protein inhibitors: optimization via array synthesis. Bioorg Med Chem Lett 18:2640-4 (2008) [PubMed]  Article 
Target
Name:
Cholesteryl ester transfer protein
Synonyms:
CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I
Type:
Enzyme
Mol. Mass.:
54751.53
Organism:
Homo sapiens (Human)
Description:
P11597
Residue:
493
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
  
Inhibitor
Name:
BDBM50094519
Synonyms:
(R)-1,1,1-Trifluoro-3-{(3-phenoxy-phenyl)-[3-(1,1,2,2-tetrafluoro-ethoxy)-benzyl]-amino}-propan-2-ol | (R)-1,1,1-trifluoro-3-((3-phenoxyphenyl)(3-(1,1,2,2-tetrafluoroethoxy)benzyl)amino)propan-2-ol | (R)-3-((3-(1,1,2,2-tetrafluoroethoxy)benzyl)(3-phenoxyphenyl)amino)-1,1,1-trifluoropropan-2-ol | 1,1,1-Trifluoro-3-{(3-phenoxy-phenyl)-[3-(1,1,2,2-tetrafluoro-ethoxy)-benzyl]-amino}-propan-2-ol | CHEMBL303954 | SC-795
Type:
Small organic molecule
Emp. Form.:
C24H20F7NO3
Mol. Mass.:
503.4093
SMILES:
O[C@H](CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2ccccc2)c1)C(F)(F)F
Structure:
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