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Target
Mu-type opioid receptor
Ligand
BDBM50238615
Substrate
n/a
Meas. Tech.
ChEMBL_477925 (CHEMBL923550)
Ki
10±n/a nM
Citation
 Tidgewell, K; Groer, CE; Harding, WW; Lozama, A; Schmidt, M; Marquam, A; Hiemstra, J; Partilla, JS; Dersch, CM; Rothman, RB; Bohn, LM; Prisinzano, TE Herkinorin analogues with differential beta-arrestin-2 interactions. J Med Chem 51:2421-31 (2008) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50238615
Synonyms:
CHEMBL264967 | Thiophene-2-carboxylic Acid (2S,4aR,6aR,7R,9S,10aS,10bR)-7-Carbomethoxy-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-9-yl Ester | Thiophene-3-carboxylic Acid (2S,4aR,6aR,7R,9S,10aS,10bR)-7-Carbomethoxy-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-9-yl Ester
Type:
Small organic molecule
Emp. Form.:
C26H28O8S
Mol. Mass.:
500.561
SMILES:
COC(=O)[C@@H]1C[C@H](OC(=O)c2cccs2)C(=O)[C@H]2[C@@]1(C)CC[C@H]1C(=O)O[C@@H](C[C@]21C)c1ccoc1 |r|
Structure:
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