Target
NAD-dependent protein deacetylase sirtuin-2
Ligand
BDBM50376978
Substrate
n/a
Meas. Tech.
ChEMBL_479067 (CHEMBL933818)
EC50
>300000±n/a nM
Citation
 Milne, JCLambert, PDSchenk, SCarney, DPSmith, JJGagne, DJJin, LBoss, OPerni, RBVu, CBBemis, JEXie, RDisch, JSNg, PYNunes, JJLynch, AVYang, HGalonek, HIsraelian, KChoy, WIffland, ALavu, SMedvedik, OSinclair, DAOlefsky, JMJirousek, MRElliott, PJWestphal, CH Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 450:712-716 (2007) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-2
Synonyms:
NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2)
Type:
Hydrolase
Mol. Mass.:
43172.62
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
389
Sequence:
MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKPQ
  
Inhibitor
Name:
BDBM50376978
Synonyms:
CHEMBL403308 | SRT-2183
Type:
Small organic molecule
Emp. Form.:
C27H24N4O2S
Mol. Mass.:
468.57
SMILES:
O[C@@H]1CCN(Cc2csc3nc(cn23)-c2ccccc2NC(=O)c2ccc3ccccc3c2)C1
Structure:
Search PDB for entries with ligand similarity: