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Target11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2)
LigandBDBM50239401
Substrate/Competitorn/a
Meas. Tech.ChEMBL_480091
IC50>10000±n/a nM
Citation Zhu, YOlson, SHGraham, DPatel, GHermanowski-Vosatka, AMundt, SShah, KSpringer, MThieringer, RWright, SXiao, JZokian, HDragovic, JBalkovec, JM Phenylcyclobutyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I. Bioorg Med Chem Lett18:3412-6 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2)
Name:11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2)
Synonyms:11-DH2 | 11-beta-HSD2 | 11-beta-hydroxysteroid dehydrogenase type 2 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | NAD-dependent 11-beta-hydroxysteroid dehydrogenase
Type:Enzyme
Mol. Mass.:42201.46
Organism:Mus musculus (mouse)
Description:Purified recombinant mouse 11beta-HSD2.
Residue:386
Sequence:
MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVV
LAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPG
ALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELS
PVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIA
LLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYI
EHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRR
CFLQNFFINHLLPRALRPGQHGPAPA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50239401
NameBDBM50239401
Synonyms:3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine | CHEMBL256777 | MERCK-544
TypeSmall organic molecule
Emp. Form.C17H25N3
Mol. Mass.271.4005
SMILESC1C2CC3CC1CC(C2)(C3)c1nnc2CCCCCn12 |TLB:4:3:0.5.6:8,0:5:1.8.2:9,0:1:5.6.4:9,THB:4:5:8:2.3.9|
Structure
n/a