Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetGrb2-SH2
LigandBDBM50264469
Substrate/Competitorn/a
Meas. Tech.ChEMBL_539205
IC50 700000±n/a nM
Citation Long, YQXue, TSong, YLLiu, ZLHuang, SXYu, Q Synthesis and utilization of chiral alpha-methylated alpha-amino acids with a carboxyalkyl side chain in the design of novel Grb2-SH2 peptide inhibitors free of phosphotyrosine. J Med Chem51:6371-80 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Grb2-SH2
Name:Growth factor receptor-bound protein 2
Synonyms:GRB2 | GRB2 adapter protein | Growth factor receptor-bound protein 2
Type:Protein
Mol. Mass.:25205.04
Organism:Homo sapiens (Human)
Description:P62993
Residue:217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50264469
NameBDBM50264469
Synonyms:CHEMBL499251 | N-Fmoc-(R)-(alpha-Me)Adi-Leu-(3'-NH2-Tyr)-Ac6c-Asn-amide
TypeSmall organic molecule
Emp. Form.C48H62N8O11
Mol. Mass.927.0529
SMILESCC(C)C[C@H](NC(=O)[C@@](C)(CCCC(O)=O)NC(=O)OCC1c2ccccc2-c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)c(N)c1)C(=O)NC1(CCCCC1)C(=O)N[C@@H](CC(N)=O)C(N)=O |r|
Structure
n/a