Reaction Details Report a problem with these data
Target
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
Ligand
BDBM50275322
Substrate
n/a
Meas. Tech.
ChEMBL_496150 (CHEMBL1000139)
Ki
33±n/a nM
Citation
 Berardi, F; Abate, C; Ferorelli, S; de Robertis, AF; Leopoldo, M; Colabufo, NA; Niso, M; Perrone, R Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity. J Med Chem 51:7523-31 (2009) [PubMed]  Article 
Target
Name:
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
Synonyms:
EBP | EBP_CAVPO
Type:
PROTEIN
Mol. Mass.:
26684.52
Organism:
Cavia porcellus
Description:
ChEMBL_203193
Residue:
229
Sequence:
MATTSTGPLHPYWPRHLRLDHFVPNDLSAWYIVTVLFTVFGALVVTMWLLSSRASVVPLGTWRRLSVCWFAVCAFVHLVIEGWFVLYQKAILGDQAFLSQLWKEYAKGDSRYIIEDNFIICMESITVVLWGPLSLWAVIAFLRQHPSRYVLQFVISLGQIYGDLLYFLTEYRDGFQHGEMGHPIYFWFYFFFMNVLWLVIPGVLFFDSVKQFYGAQNALDTKVMKSKGK
  
Inhibitor
Name:
BDBM50275322
Synonyms:
CHEMBL485929 | cis-1-(4-(4-methoxyphenyl)cyclohexyl)-4-(pyridin-2-yl)piperazine
Type:
Small organic molecule
Emp. Form.:
C22H29N3O
Mol. Mass.:
351.4852
SMILES:
COc1ccc(cc1)[C@@H]1CC[C@@H](CC1)N1CCN(CC1)c1ccccn1 |r,wU:11.15,8.8,(8.9,-26.66,;10.23,-27.43,;11.56,-26.67,;11.56,-25.12,;12.89,-24.35,;14.23,-25.12,;14.23,-26.67,;12.9,-27.44,;15.56,-24.33,;16.89,-25.1,;18.22,-24.33,;18.22,-22.8,;16.88,-22.03,;15.55,-22.8,;19.55,-22.03,;20.88,-22.8,;22.21,-22.04,;22.22,-20.5,;20.88,-19.72,;19.54,-20.49,;23.55,-19.73,;23.55,-18.2,;24.88,-17.43,;26.22,-18.21,;26.21,-19.75,;24.88,-20.51,)|
Structure:
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