Reaction Details Report a problem with these data
Target
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
Ligand
BDBM50275323
Substrate
n/a
Meas. Tech.
ChEMBL_496150 (CHEMBL1000139)
Ki
14±n/a nM
Citation
 Berardi, F; Abate, C; Ferorelli, S; de Robertis, AF; Leopoldo, M; Colabufo, NA; Niso, M; Perrone, R Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity. J Med Chem 51:7523-31 (2009) [PubMed]  Article 
Target
Name:
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
Synonyms:
EBP | EBP_CAVPO
Type:
PROTEIN
Mol. Mass.:
26684.52
Organism:
Cavia porcellus
Description:
ChEMBL_203193
Residue:
229
Sequence:
MATTSTGPLHPYWPRHLRLDHFVPNDLSAWYIVTVLFTVFGALVVTMWLLSSRASVVPLGTWRRLSVCWFAVCAFVHLVIEGWFVLYQKAILGDQAFLSQLWKEYAKGDSRYIIEDNFIICMESITVVLWGPLSLWAVIAFLRQHPSRYVLQFVISLGQIYGDLLYFLTEYRDGFQHGEMGHPIYFWFYFFFMNVLWLVIPGVLFFDSVKQFYGAQNALDTKVMKSKGK
  
Inhibitor
Name:
BDBM50275323
Synonyms:
CHEMBL486136 | trans-1-(4-(2-methoxyphenyl)cyclohexyl)-4-(pyridin-2-yl)piperazine
Type:
Small organic molecule
Emp. Form.:
C22H29N3O
Mol. Mass.:
351.4852
SMILES:
COc1ccccc1[C@H]1CC[C@@H](CC1)N1CCN(CC1)c1ccccn1 |r,wU:8.8,wD:11.15,(-11.09,-34.13,;-12.43,-34.91,;-12.42,-36.44,;-13.75,-37.21,;-13.75,-38.76,;-12.42,-39.53,;-11.07,-38.76,;-11.08,-37.21,;-9.75,-36.43,;-9.76,-34.89,;-8.42,-34.12,;-7.09,-34.89,;-7.09,-36.43,;-8.41,-37.19,;-5.76,-34.12,;-4.43,-34.89,;-3.1,-34.13,;-3.09,-32.59,;-4.42,-31.82,;-5.76,-32.58,;-1.76,-31.83,;-1.76,-30.29,;-.43,-29.53,;.91,-30.3,;.9,-31.84,;-.43,-32.6,)|
Structure:
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