Target
Histone deacetylase 1
Ligand
BDBM50276036
Substrate
n/a
Meas. Tech.
ChEMBL_496821 (CHEMBL1008834)
IC50
300±n/a nM
Citation
 Pescatore, GKinzel, OAttenni, BCecchetti, OFiore, FFonsi, MRowley, MSchultz-Fademrecht, CSerafini, SSteinkühler, CJones, P Optimization of a series of potent and selective ketone histone deacetylase inhibitors. Bioorg Med Chem Lett 18:5528-32 (2008) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50276036
Synonyms:
(S)-N-(7-oxo-1-(5-phenyl-1H-imidazol-2-yl)octyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamide | CHEMBL513881
Type:
Small organic molecule
Emp. Form.:
C26H29N3O4
Mol. Mass.:
447.5262
SMILES:
CC(=O)CCCCC[C@H](NC(=O)c1ccc2OCCOc2c1)c1nc(c[nH]1)-c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: