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Target
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal
Ligand
BDBM50241529
Substrate
n/a
Meas. Tech.
ChEMBL_543345 (CHEMBL1023015)
IC50
84000±n/a nM
Citation
 Freitas, RF; Prokopczyk, IM; Zottis, A; Oliva, G; Andricopulo, AD; Trevisan, MT; Vilegas, W; Silva, MG; Montanari, CA Discovery of novel Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase inhibitors. Bioorg Med Chem 17:2476-82 (2009) [PubMed]  Article 
Target
Name:
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal
Synonyms:
G3PG_TRYCR
Type:
PROTEIN
Mol. Mass.:
39070.68
Organism:
Trypanosoma cruzi
Description:
ChEMBL_973242
Residue:
359
Sequence:
MPIKVGINGFGRIGRMVFQALCEDGLLGTEIDVVAVVDMNTDAEYFAYQMRYDTVHGKFKYEVTTTKSSPSVAKDDTLVVNGHRILCVKAQRNPADLPWGKLGVEYVIESTGLFTAKAAAEGHLRGGARKVVISAPASGGAKTLVMGVNHHEYNPSEHHVVSNASCTTNCLAPIVHVLVKEGFGVQTGLMTTIHSYTATQKTVDGVSVKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTQGKLTGMSFRVPTPDVSVVDLTFTAARDTSIQEIDAALKRASKTYMKGILGYTDEELVSADFINDNRSSIYDSKATLQNNLPKERRFFKIVSWYDNEWGYSHRVVDLVRHMASKDRSARL
  
Inhibitor
Name:
BDBM50241529
Synonyms:
7-hydroxy-6-methoxy-3-(4-methoxyphenyl)-4H-chromen-4-one | CHEMBL464404 | afromosin | afrormosin | castanin | cid_5281704
Type:
Small organic molecule
Emp. Form.:
C17H14O5
Mol. Mass.:
298.2901
SMILES:
COc1ccc(cc1)-c1coc2cc(O)c(OC)cc2c1=O
Structure:
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