Target
Melanocortin receptor 5
Ligand
BDBM50268793
Substrate
n/a
Meas. Tech.
ChEMBL_523575 (CHEMBL997225)
IC50
590±n/a nM
Citation
 Qu, HCai, MMayorov, AVGrieco, PZingsheim, MTrivedi, DHruby, VJ Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 receptor. J Med Chem 52:3627-35 (2009) [PubMed]  Article 
Target
Name:
Melanocortin receptor 5
Synonyms:
MC-2 | MC5-R | MC5R | MC5R_HUMAN | Melanocortin MC5 | Melanocortin receptor (M4 and M5) | Melanocortin receptor 5 | Melanocortin receptor 5 (MC5R)
Type:
Enzyme
Mol. Mass.:
36612.92
Organism:
Homo sapiens (Human)
Description:
P33032
Residue:
325
Sequence:
MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD
  
Inhibitor
Name:
BDBM50268793
Synonyms:
Ac-Nle-c[Asp-His-DPhe-trans-4-guanidinyl-Pro-Trp-Lys]-NH2 | CHEMBL455070
Type:
Small organic molecule
Emp. Form.:
C50H67N15O9
Mol. Mass.:
1022.1621
SMILES:
CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2C[C@@H](CN2C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)N=C(N)N)C(N)=O |r,wU:46.49,21.76,12.11,41.72,4.4,39.45,wD:57.61,25.25,(17.82,-24,;16.46,-23.28,;16.41,-21.74,;15.05,-21.01,;15,-19.47,;16.31,-18.66,;16.26,-17.12,;17.56,-16.31,;14.9,-16.39,;13.64,-18.75,;13.59,-17.21,;12.33,-19.56,;10.98,-18.84,;9.67,-19.65,;9.72,-21.19,;11.08,-21.91,;8.41,-22,;7.05,-21.28,;5.75,-22.09,;4.39,-21.37,;3.08,-22.18,;1.72,-21.45,;1.67,-19.91,;.31,-19.19,;-1,-20,;.26,-17.65,;-1.1,-16.92,;-1.15,-15.39,;.08,-14.44,;-.45,-12.99,;-2,-13.05,;-3.06,-11.95,;-4.55,-12.33,;-4.96,-13.81,;-3.88,-14.9,;-2.41,-14.52,;1.57,-16.84,;2.22,-17.92,;2.54,-19.47,;2.93,-17.56,;3.55,-19.14,;5.08,-19.09,;5.51,-17.61,;4.23,-16.75,;4.18,-15.21,;2.82,-14.48,;5.49,-14.4,;5.44,-12.86,;4.08,-12.13,;4.03,-10.59,;2.68,-9.87,;1.37,-10.68,;1.42,-12.23,;2.78,-12.95,;6.85,-15.12,;8.16,-14.31,;8.11,-12.77,;9.51,-15.03,;10.82,-14.22,;10.78,-12.68,;12,-11.74,;11.49,-10.29,;9.95,-10.33,;9.51,-11.81,;9.57,-16.57,;10.92,-17.3,;12.23,-16.48,;6.03,-20.31,;7.52,-19.93,;8.28,-20.74,;8.13,-18.67,;.41,-22.27,;-.95,-21.54,;.46,-23.81,)|
Structure:
Search PDB for entries with ligand similarity: