Target
Melanocortin receptor 5
Ligand
BDBM50268800
Substrate
n/a
Meas. Tech.
ChEMBL_523579 (CHEMBL997229)
EC50
<0.1±n/a nM
Comments
Zero 20220115
Citation
 Qu, HCai, MMayorov, AVGrieco, PZingsheim, MTrivedi, DHruby, VJ Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 receptor. J Med Chem 52:3627-35 (2009) [PubMed]  Article 
Target
Name:
Melanocortin receptor 5
Synonyms:
MC-2 | MC5-R | MC5R | MC5R_HUMAN | Melanocortin MC5 | Melanocortin receptor (M4 and M5) | Melanocortin receptor 5 | Melanocortin receptor 5 (MC5R)
Type:
Enzyme
Mol. Mass.:
36612.92
Organism:
Homo sapiens (Human)
Description:
P33032
Residue:
325
Sequence:
MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD
  
Inhibitor
Name:
BDBM50268800
Synonyms:
Ac-Nle-c[Asp-His-DNal(2')-cis-4-guanidinyl-Pro-Trp-Lys]-NH2 | CHEMBL508501
Type:
Small organic molecule
Emp. Form.:
C54H69N15O9
Mol. Mass.:
1072.2208
SMILES:
CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)N=C(N)N)C(N)=O |r,wU:46.49,21.81,12.11,4.4,39.45,wD:61.66,25.25,41.77,(17.08,-28.2,;15.72,-27.49,;15.65,-25.95,;14.29,-25.23,;14.22,-23.7,;15.52,-22.87,;15.46,-21.33,;16.76,-20.51,;14.09,-20.62,;12.85,-22.98,;12.79,-21.44,;11.56,-23.81,;10.19,-23.09,;8.89,-23.93,;8.95,-25.47,;10.32,-26.17,;7.66,-26.29,;6.29,-25.58,;4.99,-26.4,;3.62,-25.69,;2.33,-26.52,;.96,-25.8,;.9,-24.26,;-.47,-23.55,;-1.77,-24.38,;-.53,-22.01,;-1.9,-21.3,;-1.97,-19.76,;-.75,-18.81,;-1.29,-17.36,;-2.83,-17.43,;-3.91,-16.34,;-5.39,-16.73,;-5.79,-18.22,;-4.71,-19.3,;-3.24,-18.91,;.77,-21.19,;1.43,-22.26,;1.77,-23.81,;2.13,-21.9,;2.76,-23.47,;4.3,-23.41,;4.72,-21.93,;3.43,-21.07,;3.37,-19.54,;2,-18.82,;4.67,-18.71,;4.6,-17.17,;3.24,-16.46,;1.94,-17.29,;.57,-16.58,;.5,-15.04,;-.85,-14.32,;-.92,-12.79,;.39,-11.96,;1.75,-12.68,;1.81,-14.22,;3.17,-14.92,;6.03,-19.42,;7.33,-18.6,;7.26,-17.05,;8.7,-19.3,;10,-18.48,;9.94,-16.94,;11.15,-15.99,;10.63,-14.55,;9.09,-14.6,;8.66,-16.08,;8.76,-20.84,;10.13,-21.56,;11.43,-20.73,;5.25,-24.61,;6.76,-24.38,;7.52,-24.99,;7.32,-22.97,;-.34,-26.63,;-1.71,-25.91,;-.27,-28.17,)|
Structure:
Search PDB for entries with ligand similarity: