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Target
5-hydroxytryptamine receptor 3A
Ligand
BDBM50081970
Substrate
n/a
Meas. Tech.
ChEMBL_592418 (CHEMBL1037804)
Ki
2.4±n/a nM
Citation
 Butini, S; Budriesi, R; Hamon, M; Morelli, E; Gemma, S; Brindisi, M; Borrelli, G; Novellino, E; Fiorini, I; Ioan, P; Chiarini, A; Cagnotto, A; Mennini, T; Fracasso, C; Caccia, S; Campiani, G Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization. J Med Chem 52:6946-50 (2009) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
5-HT3 | 5-hydroxytryptamine receptor 3A | 5HT3A_RAT | 5ht3 | Htr3 | Htr3a | Serotonin (5-HT) receptor | Zacopride site-R
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55428.70
Organism:
RAT
Description:
5-HT3 HTR3A RAT::P35563
Residue:
483
Sequence:
MPLCIPQVLLALFLSVLIAQGEGSRRRATQAHSTTQPALLRLSDHLLANYKKGVRPVRDWRKPTLVSIDVIMYAILNVDEKNQVLTTYIWYRQFWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPSIPYVYVHHQGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRTPEEVRSDKSIFINQGEWELLGVFTKFQEFSIETSNSYAEMKFYVVIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVQLVHKQDLQRPVPDWLRHLVLDRIAWLLCLGEQPMAHRPPATFQANKTDDCSAMGNHCSHVGSPQDLEKTSRSRDSPLPPPREASLAVRGLLQELSSIRHSLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS
  
Inhibitor
Name:
BDBM50081970
Synonyms:
6-(4-Methyl-piperazin-1-yl)-pyrido[2,3-e]pyrrolo[1,2-a]pyrazine | 6-(4-methylpiperazin-1-yl)pyrido[2,3-e]pyrrolo[1,2-a]pyrazine | CHEMBL423899
Type:
Small organic molecule
Emp. Form.:
C15H17N5
Mol. Mass.:
267.329
SMILES:
CN1CCN(CC1)c1nc2ncccc2n2cccc12
Structure:
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