Reaction Details Report a problem with these data
Target
Beta-carbonic anhydrase 1
Ligand
BDBM33275
Substrate
n/a
Meas. Tech.
ChEMBL_599731 (CHEMBL1048175)
Ki
7510±n/a nM
Citation
 Maresca, A; Carta, F; Vullo, D; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides. Bioorg Med Chem Lett 19:4929-32 (2009) [PubMed]  Article 
Target
Name:
Beta-carbonic anhydrase 1
Synonyms:
β-Carbonic anhydrase 1 (CA 1) | Carbonic Anhydrase (mtCA 1) | MTCA1_MYCTU | Uncharacterized protein Rv1284/MT1322 | canA | mtcA1
Type:
Enzyme
Mol. Mass.:
18186.06
Organism:
Mycobacterium tuberculosis
Description:
The recombinant GST-mtCA1 construct was cloned, expressed, and further purified from E. coli. The purified protein was used in inhibition assays.
Residue:
163
Sequence:
MTVTDDYLANNVDYASGFKGPLPMPPSKHIAIVACMDARLDVYRMLGIKEGEAHVIRNAGCVVTDDVIRSLAISQRLLGTREIILLHHTDCGMLTFTDDDFKRAIQDETGIRPTWSPESYPDAVEDVRQSLRRIEVNPFVTKHTSLRGFVFDVATGKLNEVTP
  
Inhibitor
Name:
BDBM33275
Synonyms:
azo-sulfonamide, 2e
Type:
Small organic molecule
Emp. Form.:
C13H13N4O5S2
Mol. Mass.:
369.397
SMILES:
NS(=O)(=O)c1cccc(c1)\N=N\c1ccc(NCS([O-])(=O)=O)cc1
Structure:
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