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Target
Tryptophan 2,3-dioxygenase
Ligand
BDBM50241727
Substrate
n/a
Meas. Tech.
ChEMBL_595175 (CHEMBL1040017)
IC50
>400000±n/a nM
Citation
 Röhrig, UF; Awad, L; Grosdidier, A; Larrieu, P; Stroobant, V; Colau, D; Cerundolo, V; Simpson, AJ; Vogel, P; Van den Eynde, BJ; Zoete, V; Michielin, O Rational design of indoleamine 2,3-dioxygenase inhibitors. J Med Chem 53:1172-89 (2010) [PubMed]  Article 
Target
Name:
Tryptophan 2,3-dioxygenase
Synonyms:
T23O_MOUSE | TO | TRPO | Tdo | Tdo2 | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase | Tryptophanase
Type:
PROTEIN
Mol. Mass.:
47757.90
Organism:
Mus musculus
Description:
ChEMBL_1452150
Residue:
406
Sequence:
MSGCPFAGNSVGYTLKNVSMEDNEEDRAQTGVNRASKGGLIYGNYLQLEKILNAQELQSEVKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVIARMHRVVVIFKLLVQQFSVLETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQSLRVPYNRKHYRDNFGGDYNELLLKSEQEQTLLQLVEAWLERTPGLEPNGFNFWGKFEKNILKGLEEEFLRIQAKTDSEEKEEQMAEFRKQKEVLLCLFDEKRHDYLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDTLMTKWRYNHVCMVHRMLGTKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLVPRHWVPKMNPIIHKFLYTAEYSDSSYFSSDESD
  
Inhibitor
Name:
BDBM50241727
Synonyms:
(S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid | 1-Methyl-Tryptophan | 1-methyltryptophan | CHEMBL504816 | L-1-methyl-tryptophan
Type:
Small organic molecule
Emp. Form.:
C12H14N2O2
Mol. Mass.:
218.2518
SMILES:
Cn1cc(C[C@H](N)C(O)=O)c2ccccc12 |r|
Structure:
Search PDB for entries with ligand similarity: