Reaction Details Report a problem with these data
Target
Adenosine receptor A2b
Ligand
BDBM50318268
Substrate
n/a
Meas. Tech.
ChEMBL_629514 (CHEMBL1120803)
IC50
49.8±n/a nM
Citation
 Taliani, S; La Motta, C; Mugnaini, L; Simorini, F; Salerno, S; Marini, AM; Da Settimo, F; Cosconati, S; Cosimelli, B; Greco, G; Limongelli, V; Marinelli, L; Novellino, E; Ciampi, O; Daniele, S; Trincavelli, ML; Martini, C Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation. J Med Chem 53:3954-63 (2010) [PubMed]  Article 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM50318268
Synonyms:
CHEMBL1096754 | N-(2-methyl-6-phenyl-2H-pyrazolo[3,4-d]pyrimidin-4-yl)benzamide
Type:
Small organic molecule
Emp. Form.:
C19H15N5O
Mol. Mass.:
329.3553
SMILES:
Cn1cc2c(NC(=O)c3ccccc3)nc(nc2n1)-c1ccccc1
Structure:
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