Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 5
Ligand
BDBM50115528
Substrate
n/a
Meas. Tech.
ChEMBL_630265 (CHEMBL1106474)
IC50
6±n/a nM
Citation
 Rotstein, DM; Melville, CR; Padilla, F; Cournoyer, D; Lee, EK; Lemoine, R; Petersen, AC; Setti, LQ; Wanner, J; Chen, L; Filonova, L; Loughhead, DG; Manka, J; Lin, XF; Gleason, S; Sankuratri, S; Ji, C; Derosier, A; Dioszegi, M; Heilek, G; Jekle, A; Berry, P; Mau, CI; Weller, P Novel hexahydropyrrolo[3,4-c]pyrrole CCR5 antagonists. Bioorg Med Chem Lett 20:3116-9 (2010) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 5
Synonyms:
C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor
Type:
Enzyme
Mol. Mass.:
40540.21
Organism:
Homo sapiens (Human)
Description:
P51681
Residue:
352
Sequence:
MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
  
Inhibitor
Name:
BDBM50115528
Synonyms:
(Z)-(4-((4-bromophenyl)(ethoxyimino)methyl)-4'-methyl-1,4'-bipiperidin-1'-yl)(2,6-dimethylphenyl)methanone | CHEMBL324643 | {4-[(4-Bromo-phenyl)-ethoxyimino-methyl]-4'-methyl-[1,4']bipiperidinyl-1'-yl}-(2,6-dimethyl-phenyl)-methanone
Type:
Small organic molecule
Emp. Form.:
C29H38BrN3O2
Mol. Mass.:
540.535
SMILES:
CCO\N=C(\C1CCN(CC1)C1(C)CCN(CC1)C(=O)c1c(C)cccc1C)c1ccc(Br)cc1
Structure:
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