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TargetMacrophage colony-stimulating factor 1 receptor
LigandBDBM50321372
Substrate/Competitorn/a
Meas. Tech.ChEMBL_640283
IC50 2.5±n/a nM
Citation Wilson, KJIllig, CRChen, JWall, MJBallentine, SKDesJarlais, RLChen, YSchubert, CDonatelli, RPetrounia, ICrysler, CSMolloy, CJChaikin, MAManthey, CLPlayer, MRTomczuk, BEMeegalla, SK Reducing ion channel activity in a series of 4-heterocyclic arylamide FMS inhibitors. Bioorg Med Chem Lett20:3925-9 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Macrophage colony-stimulating factor 1 receptor
Name:Macrophage colony-stimulating factor 1 receptor
Synonyms:CSF1R | Fms proto-oncogene | Macrophage colony stimulating factor receptor | Macrophage colony-stimulating factor 1 receptor (CSF1R) | Macrophage colony-stimulating factor 1 receptor (FMS) | Macrophage colony-stimulating factor 1 receptor (c-FMS) | Macrophage colony-stimulating factor 1 receptor (cFMS) | Proto-oncogene c-Fms | Tyrosine Kinase CSF1-R | c-fms
Type:Tyrosine-protein kinase
Mol. Mass.:107979.48
Organism:Homo sapiens (Human)
Description:n/a
Residue:972
Sequence:
MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTL
YSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFED
QDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSAL
MGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHN
NTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAY
LNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTY
RHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCA
ASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHN
QTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKY
KQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEAT
AFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVL
VITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGV
DTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVA
ARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWS
YGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHR
PTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIA
QPLLQPNNYQFC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50321372
NameBDBM50321372
Synonyms:4-cyano-N-(4-(2-(cyanoimino)hexahydropyrimidin-5-yl)-2-(4,4-dimethylcyclohex-1-enyl)phenyl)-1H-imidazole-2-carboxamide | CHEMBL1170997
TypeSmall organic molecule
Emp. Form.C24H26N8O
Mol. Mass.442.5162
SMILESCC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C1CNC(NC1)=NC#N |c:5,(11.18,-14.71,;11.96,-16.05,;12.71,-14.71,;10.62,-16.82,;10.63,-18.36,;11.95,-19.12,;13.29,-18.35,;13.29,-16.82,;11.95,-20.65,;10.63,-21.42,;10.62,-22.96,;11.96,-23.73,;13.29,-22.96,;13.29,-21.42,;14.6,-20.61,;15.94,-21.38,;15.94,-22.91,;17.26,-20.6,;18.67,-21.23,;19.7,-20.08,;18.92,-18.75,;17.42,-19.08,;19.53,-17.35,;20.15,-15.93,;9.3,-23.73,;7.97,-22.95,;6.62,-23.7,;6.63,-25.24,;7.96,-26.02,;9.3,-25.26,;5.3,-26.01,;3.96,-25.24,;2.63,-24.47,)|
Structure
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