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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50322244
Substrate
n/a
Meas. Tech.
ChEMBL_642593 (CHEMBL1176482)
Ki
8.07±n/a nM
Citation
 Vangveravong, S; Taylor, M; Xu, J; Cui, J; Calvin, W; Babic, S; Luedtke, RR; Mach, RH Synthesis and characterization of selective dopamine D2 receptor antagonists. 2. Azaindole, benzofuran, and benzothiophene analogs of L-741,626. Bioorg Med Chem 18:5291-300 (2010) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50322244
Synonyms:
1-((1H-Pyrrolo[2,3-b]pyridine-3-yl)methyl)-4-(4-(methylthio)phenyl)piperidin-4-ol oxalate | CHEMBL1172209
Type:
Small organic molecule
Emp. Form.:
C20H23N3OS
Mol. Mass.:
353.481
SMILES:
CSc1ccc(cc1)C1(O)CCN(Cc2c[nH]c3ncccc23)CC1
Structure:
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