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Target
Cyclin-dependent kinase 2
Ligand
BDBM7108
Substrate
n/a
Meas. Tech.
ChEMBL_660573 (CHEMBL1250281)
IC50
37±n/a nM
Citation
 Sridhar, J; Akula, N; Pattabiraman, N Selectivity and potency of cyclin-dependent kinase inhibitors. AAPS J 8:204-21 (2006) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM7108
Synonyms:
(N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(2-naphthyl)acetamide | N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(naphthalen-2-yl)acetamide | PNU-292137
Type:
Small organic molecule
Emp. Form.:
C18H17N3O
Mol. Mass.:
291.3471
SMILES:
O=C(Cc1ccc2ccccc2c1)Nc1cc(n[nH]1)C1CC1
Structure:
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