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Target
Cyclin-dependent kinase 4
Ligand
BDBM7238
Substrate
n/a
Meas. Tech.
ChEMBL_660568 (CHEMBL1250276)
IC50
300±n/a nM
Citation
 Sridhar, J; Akula, N; Pattabiraman, N Selectivity and potency of cyclin-dependent kinase inhibitors. AAPS J 8:204-21 (2006) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Homo sapiens (Human)
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
  
Inhibitor
Name:
BDBM7238
Synonyms:
(3Z)-3-(1H-imidazol-5-ylmethylidene)-5-methoxy-2,3-dihydro-1H-indol-2-one | 3-(3H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one | SU9516 | cid_5289419 | imidazole indolinone driv.
Type:
Small organic molecule
Emp. Form.:
C13H11N3O2
Mol. Mass.:
241.2453
SMILES:
COc1ccc2NC(=O)C(=Cc3cnc[nH]3)c2c1 |w:10.10|
Structure:
Search PDB for entries with ligand similarity: