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Target
Kappa-type opioid receptor
Ligand
BDBM50000296
Substrate
n/a
Meas. Tech.
ChEMBL_662215 (CHEMBL1252307)
Ki
1.1±n/a nM
Citation
 Pasquinucci, L; Prezzavento, O; Marrazzo, A; Amata, E; Ronsisvalle, S; Georgoussi, Z; Fourla, DD; Scoto, GM; Parenti, C; Aricò, G; Ronsisvalle, G Evaluation of N-substitution in 6,7-benzomorphan compounds. Bioorg Med Chem 18:4975-82 (2010) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50000296
Synonyms:
CHEMBL441765 | CHEMBL482811 | U-50488H | US11492374, ID 1
Type:
Small organic molecule
Emp. Form.:
C19H26Cl2N2O
Mol. Mass.:
369.329
SMILES:
CN([C@@H]1CCCC[C@H]1N1CCCC1)C(=O)Cc1ccc(Cl)c(Cl)c1 |r|
Structure:
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