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Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50335039
Substrate
n/a
Meas. Tech.
ChEMBL_702737 (CHEMBL1657811)
IC50
10±n/a nM
Citation
 Fan, Y; Jiang, T; Cashion, DK; Sun, Z; Tian, F; DaRe, J; Lemus, R Discovery of a series of phosphonic acid-containing thiazoles and orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase. J Med Chem 54:153-65 (2011) [PubMed]  Article 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:
Protein
Mol. Mass.:
36843.58
Organism:
Homo sapiens (Human)
Description:
Liver FBPase (P09467)
Residue:
338
Sequence:
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
  
Inhibitor
Name:
BDBM50335039
Synonyms:
2-Amino-5-cyclopropylmethyl-4-[2-(5-phosphono)furanyl]-thiazole | CHEMBL1650184
Type:
Small organic molecule
Emp. Form.:
C13H17N2O4PS
Mol. Mass.:
328.324
SMILES:
Nc1nc(-c2ccc(o2)P(O)(O)=O)c(s1)C1CCCCC1
Structure:
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