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Target
Adenosine receptor A3
Ligand
BDBM50214981
Substrate
n/a
Meas. Tech.
ChEMBL_730137 (CHEMBL1696017)
Ki
1.66±n/a nM
Citation
 Hou, X; Kim, HO; Alexander, V; Kim, K; Choi, S; Park, SG; Lee, JH; Yoo, LS; Gao, ZG; Jacobson, KA; Jeong, LS Discovery of New Human A(2A) Adenosine Receptor Agonists: Design, Synthesis, and Binding Mode of Truncated 2-Hexynyl-4'-thioadenosine. ACS Med Chem Lett 9:516-520 (2010) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50214981
Synonyms:
(2R,3R,4S)-2-(2-chloro-6-(3-chlorobenzylamino)-9H-purin-9-yl)tetrahydrothiophene-3,4-diol | (2R,3R,4S)-2-(6-(3-chlorobenzylamino)-2-chloro-9H-purin-9-yl)-tetrahydrothiophene-3,4-diol | CHEMBL387921
Type:
Small organic molecule
Emp. Form.:
C16H15Cl2N5O2S
Mol. Mass.:
412.294
SMILES:
O[C@@H]1CS[C@H]([C@@H]1O)n1cnc2c(NCc3cccc(Cl)c3)nc(Cl)nc12 |r|
Structure:
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